UJI EFEKTIVITAS ANTIBIOTIK EKSTRAK DAUN BELIMBIMG WULUH (AVERRHOA BILIMBI L) DAN EKSTRAK HABATUSSAUDA (NIGELLA SATIVA L) TERHADAP JUMLAH LEUKOSIT MENCIT JANTAN (MUS MUSCULUS L) YANG TERINFEKSI STAPHYLOCOCCUS AUREUS
Infectious disease is a disease caused by microorganisms that attack host, one of which is skin infection by Staphylococcus
aureus. Some types of diseases that can be caused by Staphylococcus aureus infections are pyoderma, nosocomial
infections, infections of wounds, food poisoning, and toxic shock syndrome. Indonesian people have long been applying
traditional medicine, using plants that are believed to be efficacious to treat diseases. Plants that can be used as traditional
medicine are leaves of starfruit and habatussauda starfruit. Based on previous research, this plant contains compounds that
are as antibacterial. To determine the effectiveness of antibiotic extract of starfruit leaf extract (Averrhoa bilimbi L) with
habatussauda extract (Nigella sativa L) on the number of leukocytes in male mice (Mus musculus L) infected with
Staphylococcus aureus. This study is an experimental study with a Post test with Control Group Design method. Mice were
divided into 6 groups namely K (-), K (+), P1, P2, P3 and P4 with a total sample of 6 groups. All mice were cut on the back
and infected with Staphylococcus aureus. Administered orally by force-feeding. Based on the results of hypothesis testing
with the Kruskal Walis test p value = 0.007 (p <0.05), there were significant differences in the number of leukocytes in the 6
study groups. There was a difference in effectiveness in reducing the number of leukocytes in male mice infected with
Staphylococcus aureus in the treatment group. Group K (+) is the most effective group to reduce the number of leukocytes.
Then followed by groups P4, P3, P2 and P1.