EFEK PEMBERIAN REBUSAN KULIT MARKISA UNGU (PASSIFLORA EDULIS) SEBAGAI ANTIDIABETIK TERHADAP GAMBARAN HISTOPATOLOGI PANKREAS TIKUS YANG DIINDUKSI STREPTOZOTOSIN

USWATUL KHOIROT; EMNI PURWONINGSIH; HUMAIRAH MEDINA LIZA LUBIS; LITA SEPTINA

USWATUL KHOIROT UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA
EMNI PURWONINGSIH UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA
HUMAIRAH MEDINA LIZA LUBIS UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA
LITA SEPTINA UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA

Keywords: Diabetes Melitus, Pancreas, Streptozotocin, Purple Passion Fruit

Abstract

DM is one of the greatest health problems around the world. Nowdays, we found many studies proved many plants which
contain antioxidant have a potential as antidiabetic. Antioxidants are able to repair oxidative stress in pancreatic beta cells
that overcome pancreatic tissues damage. One of the plant that contains rich antioxidant is purple passion fruit ( Passiflora
eduils). This study used True Experimental method, with Post –Test Only Control Group Design, which only gave an
observation to a control group after being given a treatment. The sample of this study was white Wister strain male rats
(Rattus Norvegisus L). The statistic study of this research used Kruskal Wallis and Mann-Whitney with a significance level of
p > 0,05, because the data were not normally distributed. Pancreatic histopathology improvement in the first treatment group
showed a non-significant difference compared with positive controlled group (p< 0, 05). Pancreatic histopathology
improvement in the second treatment group showed a significant different compared with positive controlled group
(p< 0, 05). There was an effect of giving purple passion fruit skin decoction (Passiflora eduils) as anti-diabetic to the rat
pancreas histopathology that inducted by streptozotosin.